The relation between -synuclein and cancer
Salem A. Sultan, Nuri H. Awayn
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The -synuclein gene is a member of the human synuclein genes (, and ). The sequence data of the human synuclein genes showed that -synuclein is similar by 55.9% of -synuclein and 54.3% of -synuclein sequence. The -synuclein gene sequence is highly similar to breast cancer-specific gene one (BCSG1). -synuclein was found to be expressed at high levels in aging cerebral cortex, and also in breast tumours. -synuclein or (BCSG1) was found highly increased in infiltrating breast cancers compared with normal breast tissues and benign cancers. Here, we investigate the expression of -synuclein gene in a number of different cancer cell lines. These cell lines were derived from normal breast (HBL 100), hepatocarcinoma (SK-HEP1), vulval epidermoid carcinoma (A431), human metastatic breast cancer (MDA-MB231, T47D, and MCF-7), and human ovarian cancer (PEO1). Our data were confirmed the differential expression of the -synuclein gene in breast and ovarian cancer cell lines. Furthermore, our data did not show the reported two polymorphisms in the coding region of the -synuclein gene (G C at position 243 and T A at position 377). All those together suggests that the -synuclein gene may involved in the aetiology of the breast and ovarian cancers.